Protein

UniProt accession

A0A0K1LQP3 [UniProt]

Protein name

Pre-baseplate central spike protein

PhaLP type

endolysin

evidence: UniProt function annotation

probability: 99 % (predicted by ML model)

Protein sequence

MKLGGNLHSPFFDGVVENVDDPRGLGRVQVRVFGQHPAQKQKSDAIGVPVEDLPWMMPIQDIRSAAISGVGFSPTGITRGSFVVGYWRDKWHQDGMIIGTVAGEYVEQPDTQKGFCDPMGEYPRYVGNDVNSLALGGLKGKGSSSVIIRDSNTSIAVNPDDRPLDEIPEDNRPDTGGFTIEKMLKQDEGIRTRWYTDSEGYPTIGIGHLLIREKTRDTAKINAAISKAVGREVTNGTITAEEVSTLFAQDLAKVRSDIQRTANVREVYVNLNRPRQMAIENMSFQMGVGGVAKFTNTLKAMKNEDWQAAYNGLRNSLWASQTPGRSSRVSKIVLTGNLESYGVQVPDPEGRSLSAAYAAYNGATLSATSPEDPFTPGDTRVMFEEPASSYNAEYPYNMVFESRSGHIQEFDDTPGYERYNRVHPAGSYEEIRPDGTRVVKIVGDDYQIVMQGRKLNVKGNLQVVIEGDAFIYNMGNVQQTVDGNVTEFVRGNVQQTVEGEYVGLIKGNAELTVNKDATVNVDQNLTANVKQNATVAVTEDATVTAKNAKIEIEETMDIGAKDINIKATNNTFIDSGALTKITGGTVQVG

Physico‐chemical properties

protein length:	589 AA
molecular weight:	64318,00000 Da
isoelectric point:	5,06625
aromaticity:	0,07301
hydropathy:	-0,45263

Domains

Domains [InterPro]

IPR010609

467–490

IPR010609 IPR023347 IPR009590

IPR001165

181–200

IPR001165

IPR023346

132–345

IPR023346

IPR046397

4–589

IPR046397

IPR052619

179–340

IPR052619

IPR002196

185–314

IPR002196

Protein sequence: A0A0K1LQP3

1 589

Legend: Pfam SMART CDD TIGRFAM HAMAP SUPFAM PRINTS Gene3D PANTHER Other

Domains [InterPro]

InterPro ID	Start	End	Source	Name
IPR010609	467	490	Pfam	Gp5, C-terminal
IPR023347	178	344	Gene3D	Lysozyme domain superfamily
IPR009590	34	174	Pfam	Protein Gp5, N-terminal OB-fold domain
IPR001165	181	200	PRINTS	T4-type lysozyme
IPR023346	132	345	SUPFAM	Lysozyme-like domain superfamily
IPR046397	4	589	HAMAP	Pre-baseplate central spike protein Gp5
IPR052619	179	340	PANTHER	Bacteriophage lysozyme-like
IPR002196	185	314	Pfam	Glycoside hydrolase, family 24

Taxonomy

	Name	Taxonomy ID	Lineage
Phage	Klebsiella phage Matisse [NCBI]	1675607	Straboviridae > Slopekvirus > Slopekvirus matisse
Host	Klebsiella pneumoniae [NCBI]	573	Bacteria > Proteobacteria > Gammaproteobacteria > Enterobacteriales > Enterobacteriaceae > Klebsiella

Coding sequence (CDS)

Genbank protein accession

AKU44503.1 [NCBI]

Genbank nucleotide accession

KT001918 [NCBI]

CDS location

range 106571 -> 108340
strand +

CDS

ATGAAATTAGGCGGAAATTTACACTCACCTTTCTTTGACGGGGTGGTTGAAAACGTTGATGATCCGCGCGGGTTGGGCCGTGTTCAAGTCCGTGTATTTGGACAACACCCAGCCCAAAAACAAAAATCCGATGCAATCGGTGTTCCTGTTGAAGATTTACCCTGGATGATGCCTATTCAGGATATTAGAAGCGCTGCGATCTCTGGTGTGGGCTTCTCTCCAACTGGTATCACTCGCGGATCCTTTGTTGTTGGTTATTGGCGTGACAAATGGCACCAAGATGGTATGATAATCGGTACTGTCGCTGGTGAATATGTCGAACAACCAGACACACAGAAAGGTTTTTGCGATCCTATGGGTGAATACCCTCGCTATGTTGGTAACGATGTTAACTCCCTTGCATTAGGTGGTTTGAAAGGCAAAGGATCATCAAGTGTCATCATTCGTGATTCAAACACAAGCATAGCAGTAAACCCAGACGATCGCCCACTGGATGAGATACCAGAAGATAACCGCCCTGATACGGGTGGATTTACGATCGAAAAGATGCTCAAGCAGGATGAGGGGATCCGTACACGCTGGTATACAGACAGTGAAGGATATCCGACAATCGGGATCGGGCATTTGCTTATCCGCGAAAAGACTCGCGACACTGCAAAAATTAACGCTGCGATCAGTAAAGCGGTAGGTCGAGAAGTAACAAACGGGACAATCACGGCAGAAGAGGTATCAACCTTATTTGCTCAAGATTTAGCCAAAGTAAGATCTGATATTCAGAGAACCGCTAACGTCCGTGAAGTGTATGTGAACCTAAACCGTCCTCGTCAAATGGCGATCGAAAACATGTCGTTTCAAATGGGCGTCGGTGGTGTTGCTAAATTCACCAATACCCTAAAAGCGATGAAAAATGAAGATTGGCAAGCGGCTTATAATGGTCTTCGAAATTCACTGTGGGCTAGTCAAACTCCAGGCCGTTCTTCTCGCGTGTCTAAAATCGTCCTCACGGGCAACCTTGAATCATATGGGGTGCAAGTACCAGATCCGGAAGGGCGCTCTCTGAGTGCTGCTTACGCTGCGTATAACGGTGCTACATTGTCGGCTACTAGTCCGGAAGATCCGTTTACTCCTGGTGATACCCGTGTGATGTTTGAAGAACCAGCATCATCTTATAATGCGGAATATCCGTATAACATGGTGTTTGAATCGAGATCCGGACACATTCAGGAATTCGATGATACCCCAGGATACGAACGATATAACCGTGTTCACCCAGCAGGGAGTTACGAAGAAATTCGCCCGGATGGAACCCGCGTTGTTAAAATCGTAGGGGATGATTATCAGATCGTGATGCAGGGCCGGAAACTCAACGTTAAAGGCAACTTACAGGTAGTTATTGAAGGCGATGCGTTCATTTACAACATGGGTAACGTTCAACAAACGGTTGATGGTAACGTAACTGAATTTGTTCGTGGAAACGTTCAACAAACGGTTGAAGGTGAGTACGTTGGCCTGATTAAAGGCAATGCTGAACTAACTGTAAACAAAGATGCAACAGTTAACGTTGATCAGAATCTTACCGCAAATGTGAAACAGAATGCAACCGTTGCTGTAACAGAAGACGCAACGGTCACTGCAAAAAATGCGAAAATTGAGATTGAAGAAACGATGGATATCGGTGCTAAAGATATCAATATCAAAGCAACGAATAACACGTTTATTGATTCTGGCGCATTAACAAAAATCACTGGCGGCACAGTACAGGTAGGCTAA

Gene Ontology

	Description	Category	Evidence (source)
GO:0003796	lysozyme activity	Molecular function	Inferred from Electronic Annotation (UniProt)
GO:0009253	peptidoglycan catabolic process	Biological process	Inferred from Electronic Annotation (InterPro)
GO:0016998	cell wall macromolecule catabolic process	Biological process	Inferred from Electronic Annotation (InterPro)
GO:0031640	killing of cells of another organism	Biological process	Inferred from Electronic Annotation (UniProt)
GO:0042742	defense response to bacterium	Biological process	Inferred from Electronic Annotation (UniProt)
GO:0098003	viral tail assembly	Biological process	Inferred from Electronic Annotation (UniProt)
GO:0098025	virus tail, baseplate	Cellular component	Inferred from Electronic Annotation (UniProt)
GO:0098932	symbiont entry into host cell via disruption of host cell wall peptidoglycan	Biological process	Inferred from Electronic Annotation (UniProt)
GO:0098994	symbiont entry into host cell via disruption of host cell envelope	Biological process	Inferred from Electronic Annotation (UniProt)

Enzymatic activity

EC Number	Entry Name	Reaction Catalyzed	Classification	Evidence	Source
3.2.1.17	lysozyme aka muramidase	D-glucosamine residues in chitodextrins	Hydrolases Glycosylases Glycosidases, i.e. enzymes hydrolyzing O- and S-glycosyl compounds	match to sequence model evidence used in automatic assertion ECO:0000256	HAMAP-Rule:MF_04151

Tertiary structure

PDB ID: upi0006a661b2_model

Method: AlphaFold3 Non-commercial

Resolution: –

Chain position: A