Protein

UniProt accession

A0A0N7CER3 [UniProt]

Protein name

Endolysin

PhaLP type

endolysin

evidence: UniProt function annotation

probability: 99 % (predicted by ML model)

Protein sequence

MKKMPEKHDLLTAMMAAKEQGIGAILAFAMAYLRGRYNGGAFKKTLIDATMCAIIAWFIRDLLVFAGLSSNLAYIASVFIGYIGTDSIGSLIKRFAAKKPESMMQISSNGITRLKREEGERLKAYSDSRGIPTIGVGHTGKVDGNSVASGMTITAEKSSELLKEDLQWVEDAISSLVRVPLNQNQYDALCSLIFNIGKSAFAGSTVLRQLNLKNYQAAADAFLLWKKAGKDPDILLPRRRRERALFLS

Physico‐chemical properties

protein length:	248 AA
molecular weight:	27217,00000 Da
isoelectric point:	9,66995
aromaticity:	0,08065
hydropathy:	-0,00161

Domains

Domains [InterPro]

IPR051018

103–248

IPR051018 IPR006481

IPR023346

87–248

IPR023346

IPR034690

104–248

IPR034690 IPR006481

IPR002196

115–242

IPR002196

IPR033907

110–247

IPR033907

IPR023347

103–248

IPR023347

Protein sequence: A0A0N7CER3

1 248

Legend: Pfam SMART CDD TIGRFAM HAMAP SUPFAM PRINTS Gene3D PANTHER Other

Domains [InterPro]

InterPro ID	Start	End	Source	Name
IPR051018	103	248	PANTHER	Bacteriophage Glycosyl Hydrolase 24
IPR023346	87	248	SUPFAM	Lysozyme-like domain superfamily
IPR034690	104	248	HAMAP	Endolysin T4 type
IPR006481	3	99	NCBIfam	Bacteriophage lambda, GpS, holin
IPR006481	9	99	NCBIfam	Bacteriophage lambda, GpS, holin
IPR002196	115	242	Pfam	Glycoside hydrolase, family 24
IPR033907	110	247	CDD	Endolysin/autolysin
IPR023347	103	248	Gene3D	Lysozyme domain superfamily

Taxonomy

	Name	Taxonomy ID	Lineage
Phage	Salmonella phage 22 [NCBI]	1654885	Lederbergvirus > Salmonella phage P22
Host	No host information

Coding sequence (CDS)

Genbank protein accession

AKJ74322.1 [NCBI]

Genbank nucleotide accession

KR296686 [NCBI]

CDS location

range 8700 -> 9446
strand -

CDS

ATGAAAAAGATGCCAGAAAAACATGATCTGTTAACCGCCATGATGGCGGCAAAGGAACAGGGCATCGGGGCAATCCTTGCGTTTGCAATGGCGTACCTTCGCGGTCGGTATAATGGCGGTGCGTTTAAGAAAACACTAATAGACGCAACGATGTGCGCCATTATCGCCTGGTTCATTCGTGACCTTTTAGTCTTCGCCGGACTGAGTAGCAATCTTGCTTACATAGCGAGTGTGTTTATCGGCTACATCGGCACAGACTCGATTGGTTCGCTAATCAAACGCTTCGCTGCTAAAAAGCCGGAGTCGATGATGCAAATCAGCAGTAACGGAATCACCAGATTAAAACGTGAAGAAGGTGAGAGACTAAAAGCCTATTCAGATAGCAGGGGGATACCAACCATTGGGGTTGGGCATACCGGAAAAGTGGATGGTAATTCTGTCGCATCAGGGATGACAATCACCGCCGAAAAATCTTCTGAACTGCTTAAAGAGGATTTGCAGTGGGTTGAAGATGCGATAAGTAGTCTTGTTCGCGTCCCGCTAAATCAGAACCAATATGATGCGCTATGTAGCCTGATATTCAACATAGGTAAATCAGCATTTGCCGGCTCTACCGTTCTTCGCCAGTTGAATTTAAAGAATTACCAGGCAGCAGCAGATGCTTTCCTGTTATGGAAAAAAGCTGGTAAAGACCCTGATATTCTCCTTCCACGGAGGCGGCGAGAAAGAGCGCTGTTCTTATCGTGA

Gene Ontology

	Description	Category	Evidence (source)
GO:0003796	lysozyme activity	Molecular function	Inferred from Electronic Annotation (UniProt)
GO:0009253	peptidoglycan catabolic process	Biological process	Inferred from Electronic Annotation (InterPro)
GO:0016020	membrane	Cellular component	Inferred from Electronic Annotation (UniProt)
GO:0016998	cell wall macromolecule catabolic process	Biological process	Inferred from Electronic Annotation (InterPro)
GO:0030430	host cell cytoplasm	Cellular component	Inferred from Electronic Annotation (UniProt)
GO:0042742	defense response to bacterium	Biological process	Inferred from Electronic Annotation (UniProt)
GO:0044659	viral release from host cell by cytolysis	Biological process	Inferred from Electronic Annotation (InterPro)

Enzymatic activity

EC Number	Entry Name	Reaction Catalyzed	Classification	Evidence	Source
3.2.1.17	lysozyme aka muramidase	D-glucosamine residues in chitodextrins	Hydrolases Glycosylases Glycosidases, i.e. enzymes hydrolyzing O- and S-glycosyl compounds	match to sequence model evidence used in automatic assertion ECO:0000256	ARBA:ARBA00000632

Tertiary structure

PDB ID: upi00070695fd_model

Method: AlphaFold3 Non-commercial

Resolution: –

Chain position: A