Protein

UniProt accession
I6ZRF8 [UniProt]
Protein name
Baseplate central spike protein
PhaLP type
endolysin

evidence: UniProt function annotation

probability: 99 % (predicted by ML model)

Protein sequence
MLKGIDRFFTGVVEDRQDPYMLGRVRVRVHGIHPEQKVRADNYGLATEDLLWMSVGMPVTSASVSGVGQAPVGIVTGTHVYGIFLDEFYQNGLVLGTYQGIYPMMPDFNKGFSDPSREYPRYVGSDVNILARGGKEIKISPGQIVKENQIVPVVVEDQNLNRDVAQGANRTPNDEIYPNPDPDVTIEDMLRYDEGIRVSVYWDSEGYPTVGIGHLIVHEKTRNMTRINQLLSQQVGRQVNGRITEEECSMLFERDFSSVYSSISSNSKVGPVYSMLDDTRKMAIVNMTFQMGVGGVADFNMMLGYLALGQYDNAADAALDSLWARQTPSRARRVSEVIRNGNLVPYGGSQGSAPSMQTMRMFKAASVSSTAQAPSFTEPESPYSAVYPYNKVYESESGHIQEFDDTPGHERIKTYHRTGTFEEIHPDGTKVTKIIGDDFYIVKNDGNVHIGGKLKIVVDGDADIFVQGDSNSTISGNATQFVRGNVDERVEGNVNQYVTGNSTALVKGNLNADVEGNADIKVMGDCFNTIDGNYTLKIGGNFSTEVGGSRTDDVSGNWNRQSAQVSDVAQGTFSIDGSRINLG
Physico‐chemical
properties
protein length:583 AA
molecular weight:63939,00000 Da
isoelectric point:4,95786
aromaticity:0,08405
hydropathy:-0,39931

Domains

Domains [InterPro]
IPR010609
532–555
IPR010609 IPR023346
IPR009590
31–183
IPR009590 IPR052619
IPR046397
1–583
IPR046397
IPR001165
207–225
IPR001165
IPR002196
194–318
IPR002196
IPR023347
184–346
IPR023347
Protein sequence: I6ZRF8
1 583
Legend: Pfam SMART CDD TIGRFAM HAMAP SUPFAM PRINTS Gene3D PANTHER Other

Taxonomy

  Name Taxonomy ID Lineage
Phage Aeromonas phage Aes012
[NCBI] 		1198014 Straboviridae > Tulanevirus > Tulanevirus aes12
Host Aeromonas sp.
[NCBI] 		647 Bacteria > Proteobacteria > Gammaproteobacteria > Aeromonadales > Aeromonadaceae > Aeromonas

Coding sequence (CDS)

Coding sequence (CDS)
Genbank protein accession
AFN69767.1 [NCBI]
Genbank nucleotide accession
JN377895 [NCBI]
CDS location
range 73785 -> 75536
strand -
CDS
ATGTTAAAAGGTATTGATAGATTTTTTACTGGCGTCGTAGAAGATCGTCAGGATCCGTATATGCTAGGAAGGGTGAGAGTGCGTGTACACGGTATTCACCCAGAACAAAAGGTTAGAGCAGACAACTATGGTTTAGCAACCGAGGATTTGCTGTGGATGTCAGTAGGCATGCCTGTAACATCAGCGTCAGTTTCGGGTGTAGGCCAGGCTCCAGTAGGTATTGTCACTGGTACGCACGTATACGGAATTTTCTTGGATGAATTTTATCAAAATGGCCTAGTTCTCGGGACATATCAAGGCATATATCCAATGATGCCTGATTTCAATAAAGGTTTTTCTGACCCATCAAGAGAATATCCTCGGTACGTTGGGTCAGATGTGAATATTTTGGCTAGAGGTGGAAAAGAAATAAAAATTTCACCAGGCCAAATTGTAAAAGAAAACCAAATTGTTCCAGTTGTCGTAGAAGATCAAAATCTCAACAGAGATGTTGCGCAAGGTGCAAATAGAACACCCAATGACGAAATATACCCAAATCCAGATCCAGACGTAACAATAGAGGATATGCTACGTTATGACGAAGGTATTCGTGTATCGGTTTATTGGGACAGTGAAGGATATCCAACTGTTGGAATAGGTCATTTGATAGTTCACGAAAAAACTAGAAATATGACAAGAATAAACCAATTGCTCAGTCAACAAGTAGGCAGGCAGGTTAATGGGAGAATAACCGAAGAAGAATGCTCTATGCTGTTTGAACGCGATTTTTCCAGCGTCTATTCTAGCATATCAAGCAATTCCAAGGTCGGCCCGGTATATTCGATGCTAGACGATACTCGTAAAATGGCTATTGTCAATATGACGTTCCAAATGGGTGTTGGTGGTGTAGCAGATTTTAATATGATGCTAGGATACTTGGCACTAGGCCAATACGATAACGCGGCTGATGCTGCTCTCGATTCGTTATGGGCTAGACAAACTCCATCACGAGCTCGTCGTGTGTCAGAAGTCATAAGAAATGGAAACTTGGTGCCATACGGCGGGTCACAAGGATCTGCGCCGTCGATGCAGACGATGAGAATGTTCAAAGCGGCAAGTGTATCATCAACCGCCCAAGCTCCCTCGTTCACTGAGCCTGAATCACCTTACTCGGCTGTATATCCATATAACAAAGTGTATGAAAGTGAGTCTGGTCACATCCAGGAATTTGATGATACACCTGGGCATGAACGCATAAAAACATATCACCGGACTGGTACGTTTGAAGAAATACACCCTGATGGAACAAAAGTCACGAAAATTATTGGTGATGATTTCTACATAGTCAAGAACGATGGGAATGTTCATATTGGTGGAAAACTCAAGATCGTTGTCGACGGGGATGCTGATATTTTTGTCCAAGGCGATTCTAATAGCACAATATCTGGAAATGCTACCCAATTCGTTCGTGGGAATGTTGACGAGCGAGTAGAAGGTAATGTCAATCAGTATGTCACCGGAAATTCAACAGCGTTAGTAAAAGGAAATCTAAATGCGGATGTTGAAGGAAACGCTGATATTAAAGTTATGGGTGACTGTTTTAACACGATTGATGGAAATTACACTCTAAAAATTGGAGGAAATTTTTCTACCGAAGTTGGAGGAAGTAGGACAGATGATGTTTCTGGTAATTGGAATAGACAATCGGCCCAAGTATCCGATGTTGCACAAGGAACATTCTCAATTGATGGTTCTAGAATAAACTTGGGGTAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity Molecular function Inferred from Electronic Annotation (UniProt)
GO:0009253 peptidoglycan catabolic process Biological process Inferred from Electronic Annotation (InterPro)
GO:0016998 cell wall macromolecule catabolic process Biological process Inferred from Electronic Annotation (InterPro)
GO:0031640 killing of cells of another organism Biological process Inferred from Electronic Annotation (UniProt)
GO:0042742 defense response to bacterium Biological process Inferred from Electronic Annotation (UniProt)
GO:0098003 viral tail assembly Biological process Inferred from Electronic Annotation (UniProt)
GO:0098025 virus tail, baseplate Cellular component Inferred from Electronic Annotation (UniProt)
GO:0098932 symbiont entry into host cell via disruption of host cell wall peptidoglycan Biological process Inferred from Electronic Annotation (UniProt)
GO:0098994 symbiont entry into host cell via disruption of host cell envelope Biological process Inferred from Electronic Annotation (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 lysozyme
aka muramidase 		D-glucosamine residues in chitodextrins
Hydrolases
Glycosylases
Glycosidases, i.e. enzymes hydrolyzing O- and S-glycosyl compounds
 match to sequence model evidence used in automatic assertion
ECO:0000256 		HAMAP-Rule:MF_04151

Tertiary structure

PDB ID: upi000274d999_model

Method: AlphaFold3 Non-commercial

Resolution: –

Chain position: A