Protein

UniProt accession
K0NXW8 [UniProt]
Protein name
Pre-baseplate central spike protein
PhaLP type
endolysin

evidence: UniProt function annotation

probability: 99 % (predicted by ML model)

Protein sequence
MKYGGNPYSPFFEGVVENVDDPRYLGRVQVRVFGEHPAQKQKSETIGIPVEELPWMIPIQDITSAAVSGVGFSPTGIVRGSFVVGYWRDKWHQDGVILGTYAGQYTEKPDTQKGFCDPLGEYPRYVGNDVNVLARGGLDGKTSSSVVIRDANSTLAVNPDDRPLDEIPEDNRPDTGGFTIEKMIRGDEGIRLTWYYDVKGYTIGIGHFFLTAPQGTDPAVVNAALSKQIGRTVTGVPGSITAEEAGVLFQQDLAKVRNDIQNNSKVREVYVGLNRPRQMAIENMCFQMGVGGVAKFTNALAAMKAQDWKTAYNELRNSTWANQTPGRSSRVSKIVLTGNLESYGVMVPDPEGRSLSAAFSGVVLQTDSNPEDPFVPGDTRVMFEEPKSSYNASYPYNMVFESRSGHIQEFDDTPGYERYNRVHPAGTYEEIRPDGTRVVKIVGDDYLIVQQGRKVNIKGNLQVVIEGDAFIYNMGNVQQTVDGNVTEFVRGNVNQTVEGEYVGRIKGNAELTVEKDATVNVDQNLMANVKQNATVHVTEDALVTAKNAMMDIEQDFDLNAENITMVARTNTFIDSGSLTKITGGTVQVG
Physico‐chemical
properties
protein length:589 AA
molecular weight:64655,00000 Da
isoelectric point:4,93149
aromaticity:0,08489
hydropathy:-0,40187

Domains

Domains [InterPro]
IPR009590
34–174
IPR009590 IPR023347 IPR010609
IPR002196
188–322
IPR002196
IPR001165
181–200
IPR001165
IPR023346
131–348
IPR023346
IPR046397
4–589
IPR046397
IPR052619
179–342
IPR052619
Protein sequence: K0NXW8
1 589
Legend: Pfam SMART CDD TIGRFAM HAMAP SUPFAM PRINTS Gene3D PANTHER Other

Taxonomy

  Name Taxonomy ID Lineage
Phage Pseudotevenvirus RB43
[NCBI] 		115991 Straboviridae > Pseudotevenvirus >
Host Enterobacteriaceae
[NCBI] 		543 Bacteria > Proteobacteria > Gammaproteobacteria > Enterobacteriales >

Coding sequence (CDS)

Coding sequence (CDS)
Genbank protein accession
CCK74048.1 [NCBI]
Genbank nucleotide accession
HE858210 [NCBI]
CDS location
range 106076 -> 107845
strand +
CDS
ATGAAATACGGTGGAAACCCATATTCCCCTTTCTTCGAAGGGGTGGTCGAAAATGTCGATGATCCTCGTTATCTGGGGCGCGTACAAGTTCGTGTGTTCGGTGAACATCCGGCACAGAAACAAAAATCTGAAACTATCGGTATTCCGGTAGAAGAATTGCCGTGGATGATCCCTATCCAGGACATCACAAGCGCTGCTGTATCGGGTGTGGGTTTCTCTCCTACTGGTATCGTAAGGGGTAGCTTCGTTGTAGGTTACTGGCGTGATAAATGGCATCAGGACGGGGTTATATTAGGAACCTATGCAGGACAGTACACAGAAAAGCCGGATACGCAGAAAGGCTTCTGTGACCCTCTGGGTGAATATCCACGTTATGTGGGTAACGATGTCAACGTTCTGGCTCGTGGTGGTTTAGACGGTAAAACATCGTCAAGTGTTGTTATCCGTGATGCAAACAGCACACTCGCTGTTAATCCAGACGATAGGCCGTTAGATGAAATTCCAGAAGATAACCGACCGGATACTGGGGGCTTTACAATTGAAAAAATGATCCGTGGTGATGAAGGTATTCGATTGACATGGTATTATGATGTCAAAGGGTATACCATCGGGATTGGACACTTTTTCTTAACCGCTCCACAAGGTACAGATCCAGCAGTTGTTAACGCAGCGTTATCTAAACAAATTGGTAGAACTGTTACGGGTGTTCCTGGATCAATCACAGCAGAAGAAGCGGGTGTTTTATTCCAGCAAGATTTGGCTAAAGTTCGTAACGATATTCAGAATAACAGCAAAGTTCGTGAAGTTTATGTTGGGTTAAATCGCCCACGTCAAATGGCGATCGAAAACATGTGCTTCCAGATGGGTGTTGGTGGTGTCGCCAAATTTACGAATGCTCTTGCAGCAATGAAAGCACAGGATTGGAAGACAGCCTATAATGAGTTGCGAAATTCAACATGGGCTAATCAAACTCCTGGGCGTTCTTCGCGCGTATCTAAAATCGTGTTGACAGGAAACCTTGAATCATATGGTGTTATGGTTCCAGATCCAGAAGGACGCAGTTTAAGTGCTGCTTTTTCTGGTGTTGTTTTGCAAACTGATTCAAACCCAGAAGATCCGTTTGTTCCTGGCGATACTCGCGTAATGTTCGAAGAACCGAAATCATCGTATAACGCATCATATCCATATAACATGGTATTTGAATCACGTTCAGGGCATATTCAGGAATTCGATGATACACCAGGTTATGAACGATATAACCGAGTACACCCAGCAGGAACATATGAAGAAATTCGACCTGATGGAACCCGCGTTGTTAAAATAGTTGGTGATGATTATCTTATTGTTCAACAGGGCAGAAAGGTAAACATCAAAGGCAATTTACAAGTGGTAATTGAAGGTGACGCGTTCATTTACAATATGGGTAACGTTCAACAGACTGTTGACGGAAACGTGACTGAGTTTGTACGCGGAAATGTTAACCAGACTGTCGAAGGTGAATACGTTGGACGCATTAAGGGCAACGCTGAATTGACTGTTGAAAAAGATGCTACCGTAAACGTTGACCAGAATTTAATGGCTAACGTTAAACAAAACGCAACTGTTCACGTCACAGAGGATGCACTTGTTACCGCGAAAAACGCAATGATGGATATTGAGCAAGATTTCGATCTTAACGCAGAAAATATCACAATGGTTGCGCGAACAAATACATTCATCGATTCCGGTTCTCTGACTAAGATAACTGGTGGAACGGTTCAGGTGGGTTAA
Genbank protein accession
CCL97665.1 [NCBI]
Genbank nucleotide accession
HE981739 [NCBI]
CDS location
range 106079 -> 107848
strand +
CDS
ATGAAATACGGTGGAAACCCATATTCCCCTTTCTTCGAAGGGGTGGTCGAAAATGTCGATGATCCTCGTTATCTGGGGCGCGTACAAGTTCGTGTGTTCGGTGAACATCCGGCACAGAAACAAAAATCTGAAACTATCGGTATTCCGGTAGAAGAATTGCCGTGGATGATCCCTATCCAGGACATCACAAGCGCTGCTGTATCGGGTGTGGGTTTCTCTCCTACTGGTATCGTAAGGGGTAGCTTCGTTGTAGGTTACTGGCGTGATAAATGGCATCAGGACGGGGTTATATTAGGAACCTATGCAGGACAGTACACAGAAAAGCCGGATACGCAGAAAGGCTTCTGTGACCCTCTGGGTGAATATCCACGTTATGTGGGTAACGATGTCAACGTTCTGGCTCGTGGTGGTTTAGACGGTAAAACATCGTCAAGTGTTGTTATCCGTGATGCAAACAGCACACTCGCTGTTAATCCAGACGATAGGCCGTTAGATGAAATTCCAGAAGATAACCGACCGGATACTGGGGGCTTTACAATTGAAAAAATGATCCGTGGTGATGAAGGTATTCGATTGACATGGTATTATGATGTCAAAGGGTATACCATCGGGATTGGACACTTTTTCTTAACCGCTCCACAAGGTACAGATCCAGCAGTTGTTAACGCAGCGTTATCTAAACAAATTGGTAGAACTGTTACGGGTGTTCCTGGATCAATCACAGCAGAAGAAGCGGGTGTTTTATTCCAGCAAGATTTGGCTAAAGTTCGTAACGATATTCAGAATAACAGCAAAGTTCGTGAAGTTTATGTTGGGTTAAATCGCCCACGTCAAATGGCGATCGAAAACATGTGCTTCCAGATGGGTGTTGGTGGTGTCGCCAAATTTACGAATGCTCTTGCAGCAATGAAAGCACAGGATTGGAAGACAGCCTATAATGAGTTGCGAAATTCAACATGGGCTAATCAAACTCCTGGGCGTTCTTCGCGCGTATCTAAAATCGTGTTGACAGGAAACCTTGAATCATATGGTGTTATGGTTCCAGATCCAGAAGGACGCAGTTTAAGTGCTGCTTTTTCTGGTGTTGTTTTGCAAACTGATTCAAACCCAGAAGATCCGTTTGTTCCTGGCGATACTCGCGTAATGTTCGAAGAACCGAAATCATCGTATAACGCATCATATCCATATAACATGGTATTTGAATCACGTTCAGGGCATATTCAGGAATTCGATGATACACCAGGTTATGAACGATATAACCGAGTACACCCAGCAGGAACATATGAAGAAATTCGACCTGATGGAACCCGCGTTGTTAAAATAGTTGGTGATGATTATCTTATTGTTCAACAGGGCAGAAAGGTAAACATCAAAGGCAATTTACAAGTGGTAATTGAAGGTGACGCGTTCATTTACAATATGGGTAACGTTCAACAGACTGTTGACGGAAACGTGACTGAGTTTGTACGCGGAAATGTTAACCAGACTGTCGAAGGTGAATACGTTGGACGCATTAAGGGCAACGCTGAATTGACTGTTGAAAAAGATGCTACCGTAAACGTTGACCAGAATTTAATGGCTAACGTTAAACAAAACGCAACTGTTCACGTCACAGAGGATGCACTTGTTACCGCGAAAAACGCAATGATGGATATTGAGCAAGATTTCGATCTTAACGCAGAAAATATCACAATGGTTGCGCGAACAAATACATTCATCGATTCCGGTTCTCTGACTAAGATAACTGGTGGAACGGTTCAGGTGGGTTAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity Molecular function Inferred from Electronic Annotation (UniProt)
GO:0009253 peptidoglycan catabolic process Biological process Inferred from Electronic Annotation (InterPro)
GO:0016998 cell wall macromolecule catabolic process Biological process Inferred from Electronic Annotation (InterPro)
GO:0031640 killing of cells of another organism Biological process Inferred from Electronic Annotation (UniProt)
GO:0042742 defense response to bacterium Biological process Inferred from Electronic Annotation (UniProt)
GO:0098003 viral tail assembly Biological process Inferred from Electronic Annotation (UniProt)
GO:0098025 virus tail, baseplate Cellular component Inferred from Electronic Annotation (UniProt)
GO:0098932 symbiont entry into host cell via disruption of host cell wall peptidoglycan Biological process Inferred from Electronic Annotation (UniProt)
GO:0098994 symbiont entry into host cell via disruption of host cell envelope Biological process Inferred from Electronic Annotation (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 lysozyme
aka muramidase 		D-glucosamine residues in chitodextrins
Hydrolases
Glycosylases
Glycosidases, i.e. enzymes hydrolyzing O- and S-glycosyl compounds
 match to sequence model evidence used in automatic assertion
ECO:0000256 		HAMAP-Rule:MF_04151

Tertiary structure

PDB ID: upi000050502c_model

Method: AlphaFold3 Non-commercial

Resolution: –

Chain position: A