Protein

UniProt accession

P19386 [UniProt]

Protein name

Lysozyme

PhaLP type

endolysin

evidence: UniProt function annotation

probability: 99 % (predicted by ML model)

Protein sequence

MVKKNDLFIDVSSHNGYDITGILEQMGTTNTIVKISESTTYLNPCLSAQVEQSTPIGFYHFARFGGDVAEAEREAQFFLDNVPTQVKYLVLDYEDDPSGNAQANTNACLRFMQMIADAGYTPIYYSYKPFTLDNVDYQQILAQFPNSLWIAGYGLNDGNADFEYFPSMDGIRWWQYSSNPFDKNIVLLDDEEDEKPKTAGTWKQDSKGWWFRRNNGSFPYNKWEKIGGVWYYFDSKGYCLTSEWLKDNEKWYYLKDNGAMVTGWVLVGSEWYYMDDSGAMVTGWVKYKNNWYYMTNERGNMVSNEFIKSGKGWYFMNTNGELADNPSFTKEPDGLITVA

Physico‐chemical properties

protein length:	339 AA
molecular weight:	39151,00000 Da
isoelectric point:	4,53526
aromaticity:	0,17109
hydropathy:	-0,56726

Domains

Domains [InterPro]

IPR002053

5–201

IPR002053 IPR018337 IPR018337

IPR002053

9–180

IPR002053 IPR018337

IPR017853

6–185

IPR017853

IPR018077

85–197

IPR018077 IPR008270

Protein sequence: P19386

1 339

Legend: Pfam SMART CDD TIGRFAM HAMAP SUPFAM PRINTS Gene3D PANTHER Other

Domains [InterPro]

InterPro ID	Start	End	Source	Name
IPR002053	5	201	Pfam	Glycoside hydrolase, family 25
IPR018337	261	306	PROSITE	Cell wall/choline-binding repeat
IPR002053	9	180	Pfam	Glycoside hydrolase, family 25
IPR018337	243	260	PROSITE	Cell wall/choline-binding repeat
IPR018337	241	260	PROSITE	Cell wall/choline-binding repeat
IPR017853	6	185	SUPFAM	Glycoside hydrolase superfamily
IPR018077	85	197	SMART	Glycoside hydrolase, family 25 subgroup
IPR008270	10	43	PROSITE	Glycosyl hydrolases family 25, active site

Taxonomy

	Name	Taxonomy ID	Lineage
Phage	Streptococcus phage Cp-9 (Bacteriophage Cp-9) [NCBI]	10749	Salasmaviridae > Cepunavirus > Cepunavirus Cp1
Host	Streptococcus pneumoniae [NCBI]	1313	Bacteria > Firmicutes > Bacilli > Lactobacillales > Streptococcaceae > Streptococcus

Coding sequence (CDS)

Genbank protein accession

AAA72845.1 [NCBI]

Genbank nucleotide accession

M34780 [NCBI]

CDS location

range 52 -> 1071
strand +

CDS

ATGGTTAAGAAAAATGATTTATTTATAGACGTATCAAGCCACAACGGTTACGATATAACAGGAATTTTAGAGCAGATGGGAACAACAAACACGATTGTTAAAATCTCAGAAAGTACGACCTATTTAAACCCTTGCTTGTCTGCTCAAGTGGAACAGTCTACCCCTATTGGCTTTTATCACTTCGCACGCTTTGGCGGAGACGTAGCAGAAGCTGAAAGAGAAGCGCAGTTTTTCCTTGACAACGTGCCTACACAAGTTAAATACCTTGTATTGGACTATGAAGACGACCCAAGCGGAAACGCACAAGCCAACACTAACGCATGCTTACGCTTTATGCAGATGATTGCAGACGCTGGATATACACCTATTTATTATAGTTATAAACCTTTCACGCTTGATAATGTGGACTATCAGCAGATTTTAGCACAGTTCCCTAATTCTCTCTGGATTGCAGGGTATGGCTTGAATGATGGAAACGCTGATTTTGAATATTTTCCATCTATGGACGGGATAAGATGGTGGCAGTATTCTAGTAACCCGTTTGACAAGAATATTGTACTGTTAGACGATGAAGAAGACGAAAAGCCAAAGACTGCTGGAACGTGGAAACAAGACAGTAAGGGCTGGTGGTTCAGACGCAATAACGGTAGTTTCCCTTATAATAAATGGGAAAAAATCGGGGGTGTGTGGTACTACTTCGATAGTAAAGGATATTGCTTAACGAGCGAATGGCTCAAAGATAATGAAAAATGGTACTACCTCAAGGACAACGGCGCTATGGTGACTGGTTGGGTGCTAGTCGGGTCAGAGTGGTATTATATGGACGATTCAGGTGCAATGGTTACTGGTTGGGTCAAATACAAGAATAACTGGTACTATATGACAAATGAACGTGGTAACATGGTTTCTAATGAATTTATTAAATCTGGAAAAGGCTGGTATTTCATGAACACAAACGGAGAGCTTGCAGACAATCCAAGCTTTACAAAAGAACCAGACGGACTTATAACGGTAGCATAA

Gene Ontology

	Description	Category	Evidence (source)
GO:0003796	lysozyme activity	Molecular function	Inferred from Electronic Annotation (UniProt)
GO:0009253	peptidoglycan catabolic process	Biological process	Inferred from Electronic Annotation (InterPro)
GO:0016998	cell wall macromolecule catabolic process	Biological process	Inferred from Electronic Annotation (InterPro)
GO:0031640	killing of cells of another organism	Biological process	Inferred from Electronic Annotation (UniProt)
GO:0042742	defense response to bacterium	Biological process	Inferred from Electronic Annotation (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

PDB ID: upi000012ea36_model

Method: AlphaFold3 Non-commercial

Resolution: –

Chain position: A