Protein

UniProt accession
Q19ZL8 [UniProt]
Protein name
Lysin A
PhaLP type
endolysin

evidence: GO annotation

probability: 99 % (predicted by ML model)

Protein sequence
MRAGTYTLSSGFGPRWGSQHRGLDFAAKDGTPIYAAQGGTVAYIGRADGFGQWIVIDHPAADGGGTTVYGHMWDAFATGLRQGQRVEAGQLIAYVGTNGQSTGPHLHFEVHPTVWRQGSQIDPKPWLANARNPGDPAPAPAPPKGGTLATLTDPFTGELWSPNRYHPRGLGDPRWIVVHTQEGGRTARDLAAYLAQKSSQVSYHVVVDDREVLKVVAEGDAPWAAAGANKYAFHICMAGSYASWSRNKWLDVDTSDGKNEDLQLTKTAHVIAWWCDKYGIPPVWIGGRNIPPWGLDGVCGHVDLGAWGGGHTDPGPNFPRDELMRRVSQFLAGTELPPLPTPPPVTVPGTKPDQYGDWMLYRGNPRNDADRVRRVQRRLKAAYRSYAGHLEIDGDFGPLTELAVREFQRRSLLIADGIVGPNTAAALKP
Physico‐chemical
properties
protein length:429 AA
molecular weight:46613,00000 Da
isoelectric point:7,80050
aromaticity:0,09790
hydropathy:-0,45874

Domains

Domains [InterPro]
IPR011055
5–127
IPR011055 IPR036505 IPR002477
IPR036505
155–334
IPR036505 IPR016047 IPR036366
IPR002502
173–317
IPR002502 IPR050570 IPR036365
IPR002502
172–316
IPR002502 IPR011055
IPR002502
160–315
IPR002502
Protein sequence: Q19ZL8
1 429
Legend: Pfam SMART CDD TIGRFAM HAMAP SUPFAM PRINTS Gene3D PANTHER Other

Taxonomy

  Name Taxonomy ID Lineage
Phage Mycobacterium phage Orion
[NCBI] 		373409 Pegunavirus > Pegunavirus Pg1
Host Mycobacterium
[NCBI] 		1763 Bacteria > Actinobacteria > Actinobacteria > Corynebacteriales > Mycobacteriaceae >
Host Mycobacterium smegmatis
[NCBI] 		1772 Bacteria > Actinobacteria > Actinobacteria > Corynebacteriales > Mycobacteriaceae > Mycobacterium

Coding sequence (CDS)

Coding sequence (CDS)
Genbank protein accession
ABD58365.1 [NCBI]
Genbank nucleotide accession
DQ398046 [NCBI]
CDS location
range 40538 -> 41827
strand +
CDS
ATGCGCGCGGGCACCTACACACTGTCGTCCGGTTTCGGCCCGAGGTGGGGCAGCCAGCACCGTGGCCTCGATTTCGCCGCCAAGGACGGCACACCGATCTACGCTGCGCAGGGCGGCACCGTGGCCTACATCGGCAGAGCCGACGGTTTCGGGCAATGGATCGTGATCGACCACCCCGCCGCCGACGGTGGCGGCACGACCGTCTACGGACACATGTGGGACGCGTTCGCCACCGGACTACGTCAAGGGCAGCGCGTCGAGGCCGGGCAGCTCATCGCCTACGTCGGCACGAACGGTCAATCGACCGGCCCACATCTGCACTTCGAGGTGCACCCCACCGTGTGGCGGCAGGGGTCGCAGATCGATCCCAAGCCGTGGCTGGCCAACGCGCGCAACCCCGGCGACCCCGCCCCGGCACCCGCACCACCCAAGGGAGGAACATTGGCCACGCTGACAGATCCGTTCACCGGCGAGCTGTGGTCGCCGAACCGCTACCACCCGCGCGGTCTCGGCGACCCCAGGTGGATCGTGGTGCACACCCAAGAGGGCGGTCGTACGGCGCGCGACCTCGCGGCCTACCTCGCGCAGAAGTCGAGCCAGGTCTCGTATCACGTCGTGGTCGATGACCGCGAGGTGCTCAAGGTCGTCGCCGAGGGCGATGCACCGTGGGCAGCAGCGGGCGCGAACAAGTACGCGTTCCACATCTGCATGGCTGGTAGCTACGCGTCGTGGTCGCGCAACAAATGGCTCGATGTCGACACGTCCGACGGCAAGAACGAGGACTTGCAGCTCACCAAGACCGCGCACGTCATCGCATGGTGGTGCGACAAGTACGGCATCCCGCCGGTATGGATCGGTGGCCGCAACATCCCGCCGTGGGGCCTCGACGGCGTGTGCGGACACGTCGACCTCGGCGCGTGGGGCGGTGGCCACACCGACCCCGGCCCCAATTTCCCGCGCGACGAGCTCATGCGACGCGTGAGCCAATTCCTCGCGGGCACCGAGCTGCCGCCGCTGCCGACACCGCCGCCGGTCACCGTGCCGGGCACCAAGCCCGATCAGTACGGCGATTGGATGCTCTACCGAGGCAACCCGCGCAACGATGCTGACCGTGTCCGGCGCGTGCAGCGGCGGCTCAAGGCGGCGTATCGGTCCTACGCGGGTCACCTCGAAATCGATGGCGATTTCGGCCCGCTCACCGAGCTCGCGGTGCGGGAGTTCCAGCGTCGCAGCCTGCTCATCGCCGACGGCATCGTTGGCCCCAACACCGCAGCCGCCCTCAAACCGTAG

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell Biological process Inferred from Electronic Annotation (InterPro)
GO:0004222 metalloendopeptidase activity Molecular function Inferred from Electronic Annotation (InterPro)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity Molecular function Inferred from Electronic Annotation (UniProt)
GO:0009253 peptidoglycan catabolic process Biological process Inferred from Electronic Annotation (InterPro)
GO:0042742 defense response to bacterium Biological process Inferred from Electronic Annotation (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

PDB ID: upi00001d422f_model

Method: AlphaFold3 Non-commercial

Resolution: –

Chain position: A